PhD-Developed, Patented Enzymes Trusted by 200+
U.S. Clinicians, Healthcare Practitioners, and Physicians
Stop Post-Meal Bloating, Reduce Food Introlerances, and Poop Regularly*
(533 reviews)
The 5-Second Habit Ending Bloating for Thousands of Menopausal Women
Hear from women who finally enjoy their favorite foods again without bloating, gas, or discomfort after discovering the PhD-developed way to beat Gastropause with the only patented enzyme formula pre-activated with the minerals most women over 45 lack:
“This product has been outstanding! From day one my gut felt calmed and no longer inflamed. I had zero bloating after meals which has been miraculous. Thank you for creating Holozyme!!”
“I didn’t believe the hype of this line: AES ® Patented Absorption Technology. I’m like yea, yea patented technology.. we’ll see. I have tried soooo many digestive enzymes and top brands, nothing works as good as Holozyme for me. Finally, something that takes care of the bloat after eating.. every other one promises that, but didn’t deliver.”
“Had a friend tell me about the product and I gave it a go. I’m very happy with the resuts – better digestion and no more crazy gas issues especially after trying many different probiotics with no benefit of any kind.”
Bloating, gas, irregularity, feeling heavy after meals… What’s the truth behind Gastropause?
Foods you used to tolerate suddenly leave you gassy and uncomfortable. Even small meals can sit heavy, like they’re stuck. Bloating builds as the day goes on, and digestion feels slower, more unpredictable.
There are two reasons this happens during menopause.
As estrogen drops, digestive enzyme production slows. Without enough enzymes, food lingers in the gut, ferments, and leads to gas, bloating, and irregular digestion. Enzymes help your body break food down efficiently and absorb nutrients. When they’re low, digestion becomes uncomfortable and your body misses out on some of the fuel it depends on.
Second, even the enzymes you do have may not be active.
For digestive enzymes to activate, they need minerals like magnesium and zinc. Your kidneys usually keep these minerals in your body through signals from estrogen. In fact, kidneys are the second most responsive organ to estrogen in your entire body. When your estrogen levels decrease, this preservation system doesn’t work as well, with studies showing up to 35% more minerals being lost through urine instead of being kept for proper digestion.*
This is why food starts feeling heavier, digestion slows down, and symptoms like bloating, constipation, or fatigue appear so suddenly during menopause.
HoloZyme™ is the only formula designed for the way digestion changes with hormonal shifts. It delivers complete enzyme coverage, with each one pre-paired with the mineral it needs to work. The result is a clinically proven formula that starts acting immediately in the gut — helping ease bloating, gas, and the digestive issues that appear during menopause.*
Doctor-Approved
Non-GMO
Patented
Professional Grade
Doctor-Approved
Non-GMO
Patented
Professional Grade
Less Bloating, More Food Freedom, And Better Nutrient Use for Menopausal Bodies*
HoloZyme™ uses patented activation technology and a clinically proven formula with 100% enzyme coverage, each supported by its activating mineral cofactor.
Relief from Bloating, Gas,
and Irregular Digestion*
During menopause, your digestive system struggles with even familiar foods. Meals sit heavy in your stomach, gas builds up quickly, and uncomfortable bloating becomes a daily reality.
HoloZyme™ solves both challenges at once. It replaces the enzymes your body produces less of while ensuring each enzyme is pre-paired with the exact minerals it needs to activate properly. Most women notice improvement with their very first meal – food breaks down completely instead of fermenting, moves through smoothly, and bloating diminishes noticeably.*
Tolerate More Foods
Without Digestive Issues*
As estrogen plummets, foods you used to enjoy can suddenly become digestive challenges. Dairy, gluten, high-fat meals, and even healthy vegetables might now trigger bloating, discomfort, or urgent bathroom visits.
HoloZyme™’s patented formula provides complete enzyme coverage, breaking down even the most troublesome foods before they cause problems. Enjoy restaurant meals, social gatherings, and favorite treats without worrying about digestive discomfort. You’ll have the freedom to eat what you want, when you want*
Better Absorption
of Vital Nutrients*
During menopause, it’s common to feel like food just isn’t working for you anymore. You eat well, but still feel tired, puffy, or off. The types of meals that leave you feeling worse can reveal what’s going wrong:
Protein-heavy meals leave you bloated or sluggish. This may signal poor access to amino acids needed for muscle tone, hair strength, and collagen repair.
Fatty foods lead to queasiness or loose stools. That often means your body isn’t absorbing the nutrients that support hormones, skin, and steady energy.
Dairy or sugar trigger fog, irritability, or sudden bathroom trips. Without the enzymes to handle them, you miss out on calcium needed for bone strength.
Veggies and fiber cause belly swelling, sharp gas, or painful pressure. This means you’re losing essential micronutrients and prebiotic fiber that support gut health and immune function.
HoloZyme™ is clinically proven to improve the breakdown of dairy, carbs, fats, protein, and fiber. That means better absorption of nutrients that support hormone balance, energy, and skin health. You feel more nourished, and it shows — with fewer issues like fatigue, dull skin, hair thinning, and irritability.*
Trusted Globally by Top
Health Practitioners
“I do not think these products treat symptoms, instead, it is my observation that they are really altering the gut terrain”
“The science and research behind these products give me the confidence in prescribing them to my patients”
“I’ve been working in the gut microbiome field for a long time and their products have been a complete game changer”
Doctor-Approved
Non-GMO
Patented
Professional Grade
Doctor-Approved
Non-GMO
Patented
Professional Grade
Clean, safe, patented,
and clinically validated
Most enzyme supplements assume your body already has the minerals needed to activate them. HoloZyme™ doesn’t. Each enzyme comes pre-paired with its activating mineral so it starts working right away. To receive a patent, we had to prove the formula was different and we did, with six clinical studies.
HoloZyme™ also includes Activ-Blend™ dual-strain enzymes that work across your entire gut, regardless of pH. The result is a highly activated, consistently effective enzyme formula designed for real digestive issues in hormonal bodies.
Activ-Blend™ Protease
(120,000 HUT)
Breaks down proteins throughout your entire digestive tract. Essential for absorbing amino acids that help maintain lean muscle mass, support hormone balance, and promote healthy aging during menopause.
Activ-Blend™ Lipase
(700 FIP)
Fully digests fats, making it easier to absorb fat-soluble nutrients like vitamins A, D, E, and K — all key for skin elasticity, vaginal health, and hormonal support during menopause.
Activ-Blend™ Phytase
(20 FTU)
Breaks down phytic acid found in nuts, seeds, and grains. Without it, minerals like calcium, magnesium, and zinc may be blocked from absorption, increasing risk of deficiencies common in menopause.
AES ® Patented Absorption Technology
Pairs enzymes with calcium ascorbate, magnesium citrate, zinc gluconate, manganese gluconate, and HoloCarbon black mineral complex to ensure full activation and support bone health, stress response, and overall wellness in menopause.
You’re protected by a full,
60-day money back guarantee
Hey, it’s the founders Steven and Jordan here.
We didn’t set out to make another enzyme supplement. We made HoloZyme™ because nothing else worked — not for us, and not for the women we love.
Jordan’s mother passed away unexpectedly at just 52. Looking back, we realised she had spent much of her life battling gut issues — constipation, stomach pain, fatigue, and chronic headaches. She tried everything. Medications, diets, endless appointments. But nothing gave lasting relief. Her health slowly declined, and it ultimately cost her her life.
Years later, Jordan began experiencing the same symptoms. Bloating, erratic bowel movements, fatigue. He worried he might not be there to walk his daughter down the aisle — or meet his grandkids.
We researched and evaluated over 30 enzyme products on the market. Some offered minimal relief, most fell short entirely. That’s when we discovered the real problem: enzymes only work if they’re activated by specific minerals. And for people experiencing hormonal changes like women in menopause these mineral levels are already low.
That was the missing piece.
ABOVE: Steven & Jordan on Sacagawea Peak, Montana. Neither of us having to ONCE think about where the nearest bathroom was.
So we partnered with a PhD chemist to build something that had never been done before — a fully activated enzyme formula that comes pre-paired with the exact minerals each enzyme needs to function. That formula became HoloZyme™.
It delivers 100% enzyme coverage, with each enzyme pre-activated so it starts working immediately — even when your body is running low. It’s now backed by six pilot clinical studies and protected by a full-use patent because no other product works like it.
We created this to help women like you — and we’re proud to stand behind it. That’s why we offer a 60-day money-back guarantee. If it doesn’t change your life, we’ll refund you, even if the bottle is empty.
Here’s to better health,
Steven & Jordan
Doctor-Approved
Non-GMO
Patented
Professional Grade
Doctor-Approved
Non-GMO
Patented
Professional Grade
Tributyrin-X™
Backed by 6 pilot studies, HoloZyme™ uses patented technology to deliver fully active enzymes with mineral cofactors — so digestion starts on contact, without delays, guesswork, or wasted nutrients.
Activ-Blend™ Protease
(120,000 HUT)
Breaks down proteins throughout your entire digestive tract. Essential for absorbing amino acids that help rebuild tissue, support hormone balance, and speed up postpartum recovery.
Activ-Blend™ Lipase
(700 FIP)
Fully digests fats, making it easier to absorb fat-soluble nutrients like vitamins A, D, E, and K — all key for skin, hair, and hormonal support.
Activ-Blend™ Phytase
(20 FTU)
Breaks down phytic acid found in nuts, seeds, and grains. Without it, minerals like zinc, magnesium, and iron may be blocked from absorption, slowing recovery and immune repair.
AES ® Patented Absorption Technology
Pairs enzymes with calcium ascorbate, magnesium citrate, zinc gluconate, manganese gluconate, and HoloCarbon black mineral complex to ensure full activation.
DOCTOR
TRUSTED
60-DAY
GUARANTEE
8 Ways We Meet The World’s Highest Quality Standards
Developed by Gut Health Experts
HoloZyme was formulated by a team with over 15 years of experience in digestive health research. Created in partnership with a PhD researcher awarded a patent for enzyme activation technology, it’s the result of a tireless pursuit to develop the most effective and bioavailable digestive enzyme supplement available.
Manufactured in a Certified Facility
HoloZyme is manufactured in GMP-certified facilities here in the USA, adhering to the strictest safety and quality standards. Every batch undergoes rigorous quality control to ensure it meets our high standards for purity, potency, and safety.
Unmatched Purity and Quality
HoloZyme contains only pure, premium grade digestive enzymes activated with patented AES mineral technology. This means your digestive system receives highly potent and bioavailable enzymes without any unnecessary fillers.
Revolutionary Enzyme
Activation System
Our patented AES technology is a breakthrough in enzyme supplementation. It pairs each enzyme with the exact mineral cofactor needed for optimal activation. This solves the biggest problem with traditional enzyme supplements – inconsistent results due to lack of proper enzyme activation.
Free from Junk Ingredients
We take quality seriously. HoloZyme is non-GMO, gluten-free, dairy-free, soy-free, and contains zero fillers, preservatives, or artificial additives. You’re getting nothing but pure, activated enzymes in each capsule.
Unbeatable Money-Back Guarantee
We stand behind our product, as do thousands of satisfied customers. That’s why we offer a 60-day money-back guarantee. Try HoloZyme risk-free, and if you’re not completely satisfied, we’ll refund your purchase, no questions asked.
Trusted by Thousands
With over 500 5-star reviews, customers trust HoloZyme to support their digestive health and overall wellness. It’s a game-changing solution for those dealing with bloating, food sensitivities, and unpredictable digestion.
Doctor-Approved
Non-GMO
Patented
Professional Grade
Doctor-Approved
Non-GMO
Patented
Professional Grade
Frequently Asked Questions
Q1
Who is HoloZyme™ For?
Answer
HoloZyme™ is specifically designed for women experiencing menopausal digestive changes. It addresses the unique digestive challenges that occur during perimenopause, menopause, and post-menopause when enzyme production and mineral levels naturally decline due to hormonal shifts.
Q2
When will I see results?
Answer
Most menopausal women notice results within days of starting HoloZyme™. This may include less bloating after meals, reduced gas, more comfortable digestion, and the ability to enjoy foods that previously caused discomfort. Many users report feeling a difference with their very first meal, particularly with foods that had become problematic.
Q3
How is HoloZyme™ different from regular digestive enzymes?
Answer
Most enzyme supplements assume your body already has the minerals needed to activate them. This is a critical oversight for menopausal women, as estrogen decline leads to significant mineral loss. HoloZyme™ is specifically formulated to address this by pre-pairing each enzyme with its required mineral cofactor, ensuring they work effectively regardless of your body’s mineral status.
Q4
If I take Digestive Enzymes, will my body stop producing my own? Or, am I now reliant on the Digestive Enzymes?
Answer
No, taking HoloZyme™ will not cause your body to stop producing its own enzymes. HoloZyme™ is designed to supplement your natural enzyme production during menopause when it’s typically diminished. Many women adjust their dosage based on their individual needs as they move through the menopausal transition, using more during periods of heightened digestive sensitivity and less when symptoms improve.
Q5
Are your Digestive Enzymes vegan, allergen free, and Non-GMO?
Answer
Yes. HoloZyme™ is vegan, non-GMO, and free from common allergens including gluten, dairy, soy, and eggs. Our formula contains no artificial colors, flavors, preservatives, or fillers.
Q6
How long will today’s special pricing be available?
Answer
We are unable to guarantee today’s special offer beyond midnight today. Once word gets out about our Best Deal, there’ll be a mad rush.
Supplies are limited and once it’s gone, so is this special deal.
Q7
Do I need to take HoloZyme™ with every meal?
Answer
For optimal results during menopause, we recommend taking 1-2 capsules at the beginning of each meal. However, many women find they can customize based on what they’re eating – using more when consuming foods that typically cause digestive distress (like dairy, high-fat meals, or fiber-rich vegetables) and less with simpler meals.
Q8
How does the guarantee work?
Answer
Our 60-Day Money-Back Guarantee means you can try HoloZyme™ risk-free for a full 60 days. If you don’t see the results you’re hoping for—whether that’s smoother digestion, less bloating, more regular bowel movements, or just feeling lighter and more comfortable—we’ll make it right.
It doesn’t matter if you’ve used the entire bottle—if you’re not satisfied for any reason, just reach out to our support team. We’ll process your refund, no questions asked. Even if the container is empty, you’ll still get your money back.
Q9
Does HoloZyme™ help with other menopausal symptoms beyond digestion?
Answer
HoloZyme™ is specifically formulated to address digestive challenges during menopause. However, many women report that when their digestive system functions better, they experience improvements in energy levels, sleep quality, and overall comfort. These benefits likely stem from better nutrient absorption and reduced digestive distress.*
Q10
When will my order arrive?
Answer
When you order, you will instantly receive an order confirmation email. You can relax then because we are working hard to get your order out the door to you as quickly as possible!
We will ship your order directly to your home or office using a premium mail carrier, and you will have it within 5 to 10 business days of placing your order.
Products are shipped from Chicago IL, USA and we will send you a shipment notification email with tracking number as soon as your order ships so that you can track it right to your door.
The Science Behind Tributyrin-X™
Menopause disrupts digestion in ways most gut solutions fail to fix. Tributyrin-X™ is designed to restore balance, making bathroom trips effortless and predictable. Here’s how:
1. Rebalances Oxygen Levels
99% of beneficial gut bacteria thrive in a low-oxygen environment, but menopause raises oxygen levels in the gut, wiping out good bacteria while harmful strains thrive. Tributyrin-X™ replenishes butyrate, which acts as a primary energy source for colon cells, allowing them to consume oxygen efficiently. This creates a healthy, low-oxygen environment where beneficial bacteria can thrive and digestion stays on track.
2. Seals the Gut Barrier to Prevent Leaky Gut
99% of beneficial gut bacteria thrive in a low-oxygen environment, but a weakened gut lining can allow toxins and bacteria to escape into the bloodstream, causing inflammation and discomfort. Butyrate plays a critical role in maintaining tight junctions and sealing the gut barrier, protecting against leaky gut and reducing symptoms like bloating and discomfort. This means a stronger, more resilient digestive system and fewer flare-ups. raises oxygen levels in the gut, wiping out good bacteria while harmful strains thrive. Tributyrin-X™ replenishes butyrate, which acts as a primary energy source for colon cells, allowing them to consume oxygen efficiently. This creates a healthy, low-oxygen environment where beneficial bacteria can thrive and digestion stays on track.
3. Supports Smooth Gut Motility
One of the most common menopausal complaints is sluggish digestion and irregular bowel movements. Butyrate stimulates the gut’s natural wave-like muscle contractions (peristalsis), promoting smooth, efficient movement of waste through the intestines. This helps prevent constipation, gas buildup, and that uncomfortable, backed-up feeling.
4. Maintains a Diverse Microbiome
The balance between good and bad bacteria is crucial for gut health. Tributyrin-X™ supports a healthy microbiome by providing butyrate, which stabilizes gut flora diversity and reduces the growth of harmful strains. This creates a balanced environment that supports smooth digestion and consistent, effortless bowel movements.
5. Calms Inflammation and Stabilizes Mast Cells
Menopause-related gut issues often stem from heightened inflammatory responses and mast cell activation. Butyrate helps to regulate immune function, reducing inflammation and supporting healthy mast cell activity. This means fewer histamine reactions, less discomfort, and a calmer, more stable gut environment.
