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  • Rated 4.7/5 from 785+ Reviews

Holozyme™

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Less Bloating, More Food Freedom, And Better Nutrient Use for Menopausal Bodies*

for optimal results, take for at least 3 months

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non-gmo

soy free

gluten free

no fillers

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Relief from Bloating, Gas, and Irregular Digestion*
During menopause, your digestive system struggles with even familiar foods. Meals sit heavy in your stomach, gas builds up quickly, and uncomfortable bloating becomes a daily reality.

HoloZyme™ solves both challenges at once. It replaces the enzymes your body produces less of while ensuring each enzyme is pre-paired with the exact minerals it needs to activate properly. Most women notice improvement with their very first meal – food breaks down completely instead of fermenting, moves through smoothly, and bloating diminishes noticeably.*

Tolerate More Foods Without Digestive Issues*
As estrogen plummets, foods you used to enjoy can suddenly become digestive challenges. Dairy, gluten, high-fat meals, and even healthy vegetables might now trigger bloating, discomfort, or urgent bathroom visits.

HoloZyme™’s patented formula provides complete enzyme coverage, breaking down even the most troublesome foods before they cause problems. Enjoy restaurant meals, social gatherings, and favorite treats without worrying about digestive discomfort. You’ll have the freedom to eat what you want, when you want*

Backed by 6 pilot studies, HoloZyme™ uses patented technology to deliver fully active enzymes with mineral cofactors — so digestion starts on contact, without delays, guesswork, or wasted nutrients.

Most women take just 2 capsules before challenging meals, skipping easier ones. With 90 servings per bottle, you’ll have digestive support that lasts.

Activ-Blend™ Protease – pancreatic enzyme breaks down proteins
Activ-Blend™ Amylase – pancreatic enzyme breaks down carbohydrates
Activ-Blend™ Lipase – pancreatic enzyme breaks fats down
Activ-Blend™ Lactase – brush border enzyme breaks down lactose sugar
Activ-Blend™ Cellulase – a group of enzymes that break down cellulose and fiber
Activ-Blend™ Maltase – brush border enzyme breaks maltose sugars down to glucose
Activ-Blend™ Alpha-Galactosidase – brush border enzyme breaks down fibers in legumes and vegetables
Activ-Blend™ Xylanase – brush border enzyme helps to break apart carbohydrates, polyphenols, and salicylates
Activ-Blend™ Phytase – brush border enzyme breaks down phytic acid, helping with nuts and seeds
Activ-Blend™ Fructanase – microbiome enzyme that helps break down fructans in foods like garlic, onions, and asparagus
Activ-Blend™ Glucoamylase – brush border enzyme that helps break down starches in foods like potatoes, corn, and rice
Activ-Blend™ Invertase – brush border enzyme breaks down sucrose (cane sugar, etc.) and raffinose in cruciferous veggies (broccoli, etc.)
Fulvic Minerals – powerful trace mineral complex helping activate enzymes and heal the body

Regular: 2 per meal / 2 before bed
Advanced: 4 per meal / 4 before bed
Acute: 6 per meal / 6 before bed

Real Relief from Real Women

How Thousands of Women Eliminated Years of Bloating In Days

  • I had zero bloating after meals.

    “This product has been outstanding! From day one my gut felt calmed and no longer inflamed. I had zero bloating after meals which has been miraculous. Thank you for creating Holozyme!!”

    Ramona R.

  • Finally, something that takes care of the bloat after eating

    “I didn’t believe the hype of this line: AES ® Patented Absorption Technology. I’m like yea, yea patented technology.. we’ll see. I have tried soooo many digestive enzymes and top brands, nothing works as good as Holozyme for me. Finally, something that takes care of the bloat after eating.. every other one promises that, but didn’t deliver.”

    Rochelle W.

  • No more crazy gas issues

    “Had a friend tell me about the product and I gave it a go. I’m very happy with the resuts – better digestion and no more crazy gas issues especially after trying many different probiotics with no benefit of any kind.”

    julie C.

Clean, safe, patented,
and clinically validated

Complete Digestive Balance

Most enzyme supplements assume your body already has the minerals needed to activate them. HoloZyme™ doesn’t. Each enzyme comes pre-paired with its activating mineral so it starts working right away. To receive a patent, we had to prove the formula was different and we did, with six clinical studies.

HoloZyme™ also includes Activ-Blend™ dual-strain enzymes that work across your entire gut, regardless of pH. The result is a highly activated, consistently effective enzyme formula designed for real digestive issues in hormonal bodies.

Clean, safe, patented,
and clinically validated

Get the most out of Holozyme™

Experience relief in the first week, and noticeable changes within 30 days.

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Day 1–3

Meals feel lighter. Less pressure, bloating, “brick stomach.”

WEEK 1–2

More complete breakdown of foods; bowel movements feel more normal and consistent.

MONTH 1–2

Better nutrient uptake supports energy, thinking, and immune resilience.

MONTH 5+

Supports long-term digestive ease; users say, “I can eat without the after-effects.”

Month 6+

Many users report lasting digestive stability and a resilient gut they can rely on.

Customer-Proven Results You Can Trust

87%

experienced less bloating after meals*

82%

noticed reduction in gas*

91%

saw noticeable digestion improvement*

*Based on an internal survey of 105 HoloZyme users who have taken the product for 30 days or longer.

Trusted Globally by Top
Health Practitioners

Healthy Gut vs. Others

Here's how HoloZyme compares to competitors.

Benefits

HealthyGut

Others

Clean formulas with no fillers

Doses that reflect research and clinical use

Transparent ingredient labels

3rd party tested

US-based digestive coaching

Non-GMO, gluten-free, dairy-free, soy-free, zero sugar, no fillers/preservatives

60-day Money-back guarantee

Frequently asked questions

HoloZyme is for anyone who wants the digestive and systemic healing of enzymes. It’s for anyone who’s digestion is too fast, to much gas, bloat, loose, or sour. It helps get all the precious nutrients from every food you eat.
It’s for anyone who wants to systematically use enzymes to support immune function and healthy aging.
Anyone into anti-aging ideas and wanting to feel and look their best should consider HoloZyme as it has been shown to support protein, fat, and carbohydrate absorption in the body in healthy levels in 6 pilot studies.
It is especially helpful for anyone who has long standing digestive issues and or pain related complaints.

It starts with the fact that HoloZyme is the most activated enzyme on the market. It was awarded a patent for its specific activation system. This ALONE make it totally different than all the other enzymes on the market.
We’ve tried all the other brands as well and we ended up licensing these patents in order to make the most activated enzyme on the market.
Why does activation matter?
Because each enzyme needs energy to “turn on” or “activate”. This energy comes from what is called a mineral co-factor. See enzymes are deactivated until they are gifted energy to work. HoloZyme includes this energy right in the capsule versus other brands who rely on the body to do the work.
If the body lacks the co-factors to “turn-on” the enzymes it is likely to stay deactivated.
Also our Activ-Blend ™ base enzymes are dual strain and work anywhere in a pH of 1.7 to a pH of 11.0. This allows this to work anywhere in the body unlike traditional pancreatin and many other enzymes who only work in narrow pH ranges.
We include the highest ingredients in enzymes and therefore need less of them.

When I first tried it, I was worried because I react to EVERYTHING. But it has no gluten, dairy, soy, sugar, or GMOs. Just the pure butyrate in a special coating. Finally, something my sensitive gut could handle!

Mine came from Chicago and took about a week to reach me. They sent tracking info right away which was nice – I was anxiously waiting!

This was my biggest fear – wasting more money on something that wouldn’t help. But they have a 60-day guarantee, even if you use the whole bottle.


I never needed it (thank God), but knowing I could get my money back made me feel better about trying it. I mean, after 5 years of suffering, what did I have to lose?

headshot of steven wright against books

ABOVE: Steven & Jordan on Sacagawea Peak, Montana. Neither of us having to ONCE think about where the nearest bathroom was.

HoloZyme™ is:

  • Manufactured in a GMP-certified facility
  • Professional Grade
  • PhD Formulated
  • Backed by 15+ years of gut healing experience

“Partnering with a PhD chemist, we developed a patented delivery system to get pure, bioavailable butyrate directly to the colon. That’s how Tributyrin-X™ was born.

Since then, we’ve shared our knowledge with millions and helped thousands of women, especially through menopause, finally find lasting relief — backed by a 60-Day Guarantee.”

Steven Wright | founder

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